Carsil Silymarin Tolerance!

Carsil Max (Silymarin) hard capsules 30 x 110 mg

Toxicological studies

The acute, subacute and chronic toxicity was studied.

The toxic effects of Carsil were studied on laboratory animals: mice, rats and dogs.

Acute toxicity

No lethality was observed after administration of single oral doses as high as 20,000 mg/kg to mice and rats.

No behavioral change and lethality were observed after administration of oral doses as high as 1,000 mg/kg to dogs.

Subacute and Chronic toxicity

No evidence of toxic changes of the chemical laboratory and pathohistological investigations were found in rats, after oral treatment with doses of 50, 200 and 1,000 mg/kg for 3 months.

No evidence of toxic damage was detected in a chronic (6-month) trial on rats and dogs in doses of 10, 50, 100 and 200 mg/kg.

Teratological studies

No evidence of embryotoxic and tetratogenic effect was found in trials performed on rats, after oral treatment for the whole gestation period with doses of 1,000 and 2,000 mg/kg, as well as on rabbits treated orally with a dose of 100 mg/kg.

Mutagenicity studies

No evidence of existence of a mutagenic effect was found in rats, after oral treatment with doses of 10, 50, 200 mg/kg.

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