Carsil Silymarin Patient Details




Intake information

Carsil Max (Silymarin) hard capsules 30 x 110 mg

Carsil intake in adults: As a prophylactic: 2-3 tablets daily. In light and moderately severe cases 1-2 tablets three times daily. In severe forms of illness 2-3 tablets three times daily. Carsil is characterized by a very good resorption and tolerance. No side effects are observed with therapeutic doses.

Package: 80 coated tablets of 35 mg each.

Effects

Exerts a specific protective and therapeutic effect on liver cells. Stimulates the cellular metabolism and protects the liver. Has an antioxidant and anti-inflammatory effect.

    These effects are clinically manifested in:
  • Normalization of liver enzyme values.
  • Reduction of complaints relating to digestion.
  • Improvement of general status.

    Carsil is applied in
  • Acute and chronic hepatitis.
  • Liver cirrhosis.
  • Liver fatty degeneration.
  • Injury of liver functions due to poisoning.
  • As a prophylactic in increased application of substances that burden the functions of the liver: medicines, alcohol, toxic industrial substances.
  • Carsil is applied per os, and the therapeutic course continues for 3 or more months.

Indications

In chronic liver inflammation, liver dystrophy, cirrhosis, adipose degeneration resulting from hepatitis, liver impairment with functional disorders caused by poisoning, and as a prophylactic agent in cases of an increased inflow of liver function loading substances.

Position of Carsil in the comprehensive therapy of liver cirrhosis

Carsil has a good effect in the therapy of liver cirrhosis, too. The pathological biochemical values become normal in a high percentage of the cases. The above is typical above all for patients in a stage of exacerbation of the disease.

Administered to patients with liver cirrhosis prior to surgery, Carsil exhibits a favorable effect manifested by simulation of the liver functions, which reduces the surgical risk.

Of special importance is the fact that the development of ascites was prevented in decomprensated cirrhosis.

The biopsy follow-up indicates that the activity of the morbific process is reduced even in the majority of the cases with chronic active hepatitis of a considerably poorer prognosis.

The judgment of the effect of Carsil therapy in acute hepatitis is difficult, due to its inclination to spontaneous cure. However, a conclusion may be drawn from the observations so far, that Carsil has a positive effect on therapeutically unfavorable forms of hepatitis, such as the parenterally transmitted hepatitis, and the one with a tendency to cholestasis and retention, i.e. it prevents its transition to a chronic stage. A reduction of the inflammatory activity or retention of the process was found in the biopsy investigations performed.

The electron microscopy investigations show existence of predominantly intact and glycogen-rich liver parenchyma cells after Carsil therapy.

Toxometabolic liver damage

In toxometabolic liver damage by exogenous liver-loading substances (alcohol, drugs), or due to metabolic disorders (diabetes mellitus), the principal finding in the majority of the cases is the adipose of the liver, while the biochemical parameters remain normal or slightly alerted. The pathologically increased values of the transaminases, as well as the bromphthalein test, show a pronounced tendency to normalization, after Carsil therapy.

Some psychopharmacological and anticonvulsive agents are known to be capable of causing liver morphological changes, resulting in intrahepatic cholestasis, which renders their prolonged administration problematic. In patients on psychopharmacological and anticonvulsive, Carsil has had a favorable effect on 73% of the pathologically altered live parameters, with the majority of the latter being normalized.

Adverse reactions

No adverse reactions of Carsil requiring discontinuation of the therapy have been observed: either with a short-term high dosage, or in a long-lasting therapy.

A week laxative effect (diuretic respectively) was observed in some cases, which was not undesired. Sometimes vestibular disorders occur after Carsil therapy, however they subside with the discontinuation of the drug.

Contraindications

Hypersensitivity to Silymarin.

Administration and Posology

Adults: As a prophylactic: 2-3 tablets daily.In light and moderately severe cases 1-2 tablets three times dailyIn severe forms of illness 2-3 tablets three times daily Usually, 1-2 tablets are orally administered to adults 3 times daily. The daily dose may be doubled in case of severely impaired liver function. The course of therapy should be no less than three months and 70-100 mg daily prescribed for prevention.

Children: The daily dose is 5 mg/kg body mass, divided in 2-3 intakes

Supplied

35 mg tablets in packs of 80.

Storage

At a moderate temperature 60-86°F (15-30°C).

Expiry term

Two (2) years.

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